Michele SAVIANO
Insegnamento di DESIGN OF BIOACTIVE COMPOUNDS
Corso di laurea magistrale in MOLECULAR BIOTECHNOLOGY
SSD: CHIM/08
CFU: 6,00
ORE PER UNITÀ DIDATTICA: 48,00
Periodo di Erogazione: Primo Semestre
Italiano
Lingua di insegnamento | INGLESE |
English
Teaching language | English |
Contents | Structural biology of pharmacological targets and their ligands (Experimental versus computation approaches); |
Textbook and course materials | Bibliography provided by the teacher |
Course objectives | The aim of this course is to introduce the theory and practice for the design of bioactive compounds using different theoretical and experimental techniques of Structural Chemistry and Biology (X-ray diffraction, NMR spectroscopy, Computational techniques). At the end of the course,the student knows the chemical basis of the structure and structural and functional properties of natural and synthetic peptide systems and is able to understand the logic that governs their design to perform specific biological functions. It is able to find information on the structure of peptide systems and complexes with proteins and nucleic acids in databases and to analyze their spatial structure. Understands the importance, through specific examples, of knowledge of peptide chemistry in application fields such as diagnostics and pharmaceuticals. |
Prerequisites | No propaedeutic |
Teaching methods | The attendance to the lessons is mandatory. The module is organized in 48 hours of frontal lessons that will be theoretical and practical. |
Evaluation methods | The final examination will consist in an oral interview, aimed to verify the notions acquired and the ability of the student to re-elaborate the contents presented during the lessons. In particular, these oral examinations are aimed to evaluate the capability of reasoning and connecting the various topics of the course. They will consist of questions about the theoretical part of the course with the twofold scope of evaluating (a) the knowledge of the treated subjects and (b) the capability to expose and connect the diverse topics. |
Other information | During the course slides and notes of the lectures will be provided to the students via Teams. |
Course Syllabus | - Structural Biology of targets and ligands- |