INGLESE

.

English

Cells in culture and techniques for their study; Cell cycle and control of cell growth in
eukaryotes; Development of multicellular organisms: integrating cells into tissues; Signal
Transduction pathways; Cancer.

- Molecular Biology of the Cell, sixth edition, (2014), Bruce Alberts, Alexander D. Johnson, Julian
Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter . W.W. Norton & Company
- Molecular Cell Biology, Eighth Edition (2016), Harvey Lodish, Arnold Berk, Chris A. Kaiser, Monty
Krieger, Anthony Bretscher, Hidde Ploegh, Angelika Amon, Kelsey C. Martin. Macmillan Learning.
- Essential Cell Biology, Fourth edition, Bruce Alberts, Dennis Bray, Karen Hopkin, Alexander D.
Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter. W.W. Norton & Company

The course is rooted in an understanding of the molecules within cells and of the interactions
between cells that allow development of multicellular organisms. Key concepts in cellular
biochemistry and their experimental underpinnings will be presented. Medically relevant
examples will be described where appropriate to help illustrate the connections between
cellular biochemistry and health and human disease. A hallmark of the course is the use of
experiments to engage students in the history of cell biology and the research that has
contributed to the field.

Knowledge and skills in Chemistry and Biology acquired during the Bachelor courses.

Oral lessons and critical reading of original scientific papers

For the students who attend the course the exam consists of passing an oral exam with a grade of at least 18/30,
The oral exam is aimed at evaluating the knowledge of the different topics, the reasoning and connection skills between the various topics of the course.

The student can use the supporting teaching material made available on the University website.

The teacher is available for receiving students on the days indicated on the teaching form and on request sent by e-mail.

Part I: Cells, the Fundamental Units of Life
- Course Introduction
- Chemical Components of Cells, Cells, and Model Organisms
- Ways of working with cells: Culturing cells, Cell culture Media, Reagents, Cell lines, Cell
cultures, Primary Cell cultures; Visualizing cells and their components; Identifying and Analysing
molecules inside the cells and Studying their Interactions.
- Model Organisms and Trangenesis
Part II: The Cell-Division Cycle and Cell growth
- The Eukaryotic Cell Cycle and its regulation
Part III: Integrating Cells Into Tissues
- Stem Cells and Pluripotency, Cell Asymmetry.
- Transcriptional Control of Gene Expression during Development of multicellular organisms; Cell
Differentiation: Myogenesis, the muscle formation during embryonic development; The
Formation of the Primary Body Axis, the anterior–posterior axis, during embryonic development
- Cell Signaling: Signal Transduction and G Protein–Coupled Receptors, human G protein-coupled
receptors of pharmaceutical importance; Signal Transduction and Receptor Tyrosine Kinase
(RTK); Signaling Pathways that control Gene Expression; Signaling by Sensory Receptors.
- Cell Death
Part IV. Cancer
- The characteristics of cancer cells and how they differ from normal cells